suspension means the insoluble solid drugs with particles dispersed in the dispersion medium in the state of the formation of non-uniform liquid formulations. Suspension of drug particles is generally 0.5 to 10 microns to 0.1 microns can be small ones, the larger up to 50 microns or larger. Suspensions are thermodynamically unstable crude dispersion. Dispersion medium used in most of the water, can also be used vegetable oil.
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About the role of feature classification of liquid pharmaceutical suspension-type profile of pharmaceutical drugs can be solid, liquid or gas, respectively, under certain conditions, molecules or ions, particles, particles, droplets dispersed in a liquid dispersion state media (solvent, the same below) in composition dispersions. Such as the dispersed phase can be made to the minutesuspension emulsion
sub-state ions dispersed in a liquid or dispersed in the media who called the solution of (true solution), which is called low molecular weight solute molecular weight of the solution; solute molecular weight (such as protein) is known as the polymer solution. Colloidal solution in addition to the polymer solution, it also includes the sol, which consists of multi-molecular aggregates of particles as a dispersed phase, dispersed in a liquid dispersion media in. If solid particles or liquid droplets dispersed in the dispersion medium, the particles or droplets and dispersed phase interface between the media, the former known as suspension, the latter known as emulsion. According to the dispersed phase particle size and dispersion of different types of liquid pharmaceutical solution into colloidal solution type, suspension type, emulsion-type four. By application method, agents can be divided into oral liquid, topical and injected three categories. Including a variety of dosage forms, such as oral mixture, solution etc.; topical, such as lotion, liniment, gargle, nasal drops, and so on. The liquid pharmaceutical collectively referred to as dispersion medium dispersion medium, is called the dispersed phase dispersion of the drug. One solution-based colloidal solution and the dispersion of the media type is also known as pharmaceutical solvents; pharmaceutical emulsion type media, also known as Foreign Secretary,[url=http://www.moncleruksales.co.uk/][b]title=Moncler Sale UK[/b][/url], distributed or continuous phase. Existence of the physical characteristics of the storage stability of suspension problems. Suspension of drug particles in the dispersion of largesuspension
, particles and dispersion medium exists between the physical interface, the suspension of particles with high surface free energy, suspension in an unstable state . Suspension of hydrophobic drugs than hydrophilic drugs have a greater stability. To slow the suspension obtained the settlement should be reduced particle size, dispersant viscosity increase and reduce the density difference between solid and liquid. Experimental work in the first two major applications means increased stability. Thickener available syrup, natural rubber type, and the synthesis of soluble cellulose. Adding surfactants can reduce the interfacial free energy, make the system more stable, and by the surfactant as a wetting agent can be an effective solution to hydrophobic drugs in the water together. Flocculation of particles on its surface electrically charged case, the inclusion of an appropriate amount of coagulant (electrolyte) ζ potential of the particles down to a certain extent, particle flocculation occurred, relatively stable suspension, flocculation sediment bulky, easily redispersible after shaking . Joined the anti-coagulant (electrolyte) can increase the existing solid surface charge, these charged particles without flocculation mutually exclusive. Classified according to the dispersed phase particle size and dispersion of different types of liquid pharmaceutical solution into colloidal solution type, suspension type, emulsion-type four. By application method, agents can be divided into oral liquid, topical and injected three categories. Including a variety of dosage forms, such as oral mixture, solution etc.; topical, such as lotion, liniment, gargle, nasal drops, and so on. The liquid pharmaceutical collectively referred to as dispersion medium dispersion medium, is called the dispersed phase dispersion of the drug. One solution-based colloidal solution and the dispersion of the media type is also known as pharmaceutical solvents; pharmaceutical emulsion type media, also known as Foreign Secretary, distributed or continuous phase. Role of the suspension under high pressure, high-speed adjustable gap through a homogenizing valve, high-speed impact, shear and combined effect of loss of pressure explosions, the larger particles crushed into small particles, their diameter 0.01 ~ 2μm range. This purely physical process to maintain the activity of the original product, at the same time, a relatively stable emulsion. Suspension type pharmaceutical suspension type pharmaceutical drugs generally refers to insoluble particles dispersed in a liquid dispersion media in the formation of uniform disperse system of liquid agents. Requirements for suspension are: suspension of fine particles should be uniform, sinking slowly, its speed does not affect the correct amount of dosage; sinking particles do not agglomerate after a little shake that can be evenly distributed; in the long term stored in the particle size remains unchanged; not sticky, easy dumping; appearance, taste delicious and have some anti-corrosion ability; external coating suspension should be easy, easy dispersed, fast drying, easy to wipe dry to form off the protective film. Suspension of particles is generally more than 1um, used widely in medical suspension in oral, topical, injection, eye drops, such as aerosol and long-acting formulations are applied. The liquid pharmaceutical drugs can be solid, liquid or gas, respectively, under certain conditions, molecules or ions, particles,[url=http://www.uggoutletmallonline.com/][b]title=UGG Outlet Online[/b][/url], particles, droplets dispersed in a liquid dispersion state media (solvent, the same below) in composition dispersions. Such as molecular or ionic state of the dispersed phase dispersed in a liquid dispersion media in the solution are known (true solution), which is called low molecular weight solute molecular weight of the solution; large molecular weight solutes (eg proteins) are known as polymer solution. Colloidal solution in addition to the polymer solution, it also includes the sol, which consists of multi-molecular aggregates of particles as a dispersed phase, dispersed in a liquid dispersion media in. If solid particles or liquid droplets dispersed in the dispersion medium, the particles or droplets and dispersed phase interface between the media, the former known as suspension, the latter known as emulsion. Further reading: 1Baidu know http://zhidao.baidu.com
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